Researchers at Massachusetts Institute of Technology, Cambridge, MA, and Tufts Univ., Medford, MA, have developed a mathematical model that calculates the concentration of glycosaminoglycan (GAG), an indicator of cartilage development (or chondrogenesis), in bioengineered cartilage as a function of position within the tissue and cultivation time.
Each year, more than one million patients require treatment of damaged cartilage. In vitro tissue engineering has been investigated as a potential source of tissue constructs for cartilage repair, as well as a model system for studies of cartilage development and function.
The MIT/Tufts team cultured bovine cartilage cells …
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